Biotechnol.Bioeng. (1982) 24(8) 1889-96

Optimization of operating temperature for continuous glucose-isomerase reactor system.

Kim-C; Kim-H-S; Ryu-D-D-Y

Immobilized enzyme reactors subjected to enzyme deactivation can be operated optimally. Temperature is one of the most important control variables which affects reaction rate and enzyme deactivation. Some improvements in reactor performance are shown by considering enzyme loading as an additional parameter. Reaction kinetics and a reactor mathematical model were devised for the reversible enzymatic isomeration of glucose to fructose. The control vector iteration method was used. The numerical simulations of optimal control policy were performed for constant and varying temperatures; the policy improving the enzyme utilization efficiency in an immobilized enzyme reactor system and improving fructose productivity.